Annovis Bio to Present New Buntanetap Data at Parkinson Study Group Meeting, Highlighting Cognitive Benefits in Patients with Amyloid Pathology

Annovis Bio Inc. (NYSE: ANVS) will present new clinical findings for its neurodegenerative disease drug candidate buntanetap at the 2025 Annual Meeting of the Parkinson Study Group in San Diego from December 4-6. The presentation will expand on recent Phase 3 Parkinson's biomarker results showing that patients with amyloid co-pathology experience more severe cognitive decline that is reversed by buntanetap treatment. This development is significant because it identifies a specific patient subgroup that may benefit most from the therapy, potentially enabling more targeted and effective treatment approaches for neurodegenerative conditions.

The company will also debut a cross-study comparison of all completed trials, offering what it describes as the most comprehensive view to date of cognitive outcomes across different neurodegenerative disease indications. This analysis underscores that patients with amyloid pathology achieve the greatest cognitive benefit from buntanetap treatment, supporting the company's strategic development path forward. The findings are particularly important for the Parkinson's disease community, where cognitive impairment represents a major unmet medical need that significantly impacts patient quality of life and disease progression.

According to the announcement, buntanetap not only reverses cognitive decline in patients with amyloid co-pathology but also reduces tau biomarkers linked to disease progression. This dual mechanism addressing both amyloid and tau pathology could represent a significant advancement in neurodegenerative disease treatment, as most current therapies target only one pathological pathway. The implications extend beyond Parkinson's disease to other neurodegenerative conditions, including Alzheimer's disease, where similar pathological mechanisms are at play.

The presentation at the Parkinson Study Group Annual Meeting represents an important milestone for Annovis Bio as it advances its late-stage clinical drug platform. The company, headquartered in Malvern, Pennsylvania, is dedicated to addressing neurodegeneration in diseases such as Alzheimer's and Parkinson's through innovative therapies that aim to improve patient outcomes and quality of life. For more information about the company, visit https://www.annovisbio.com. The full press release detailing these developments is available at https://ibn.fm/xiBPL.

These findings have broader implications for the neurodegenerative disease treatment landscape, potentially enabling more personalized medicine approaches based on specific biomarker profiles. As the global population ages and neurodegenerative diseases become increasingly prevalent, therapies that can effectively target specific pathological mechanisms represent an important advancement in medical science. The data presentation at this prestigious scientific meeting will provide the research community with valuable insights into buntanetap's mechanism of action and therapeutic potential across multiple neurodegenerative conditions.