Drug developers are increasingly focusing on complex protein interaction networks that drive diseases, moving beyond single-target biology. Traditional in vitro assays often fail to capture interactions in native intracellular environments, particularly for membrane proteins or variant libraries. This limitation has renewed interest in yeast two-hybrid technologies, which Creative Biolabs has enhanced with refined platforms.
Creative Biolabs offers multiple two-hybrid services including yeast two-hybrid, mammalian two-hybrid, bacterial two-hybrid, and reverse yeast two-hybrid for global clients studying protein-protein interactions in biological systems. The company has improved its platform using gateway cloning technology, allowing rapid transfer of DNA sequences encoding proteins of interest into different vector systems compatible with two-hybrid assays. This refinement streamlines the setup process for researchers.
According to a Principal Scientist at a U.S. biotech company, "We were finally able to screen membrane proteins that had stalled our project for months." A Group Leader at a European research institute noted that "the reverse Y2H platform gave us a clean readout on disruptive mutations. It clarified our drug mechanism faster than expected."
Beyond two-hybrid services, Creative Biolabs provides broader discovery services to identify ideal binders tailored to specific research needs involving antibodies, peptides, or small molecules. The company emphasizes its strengths in binder discovery through precise identification technologies, diverse discovery platforms, customized project strategies, and reliable results that maintain research momentum.
As protein interaction research expands across fields from oncology to synthetic biology, Creative Biolabs positions its enhanced platform as part of a broader shift toward more integrated, mechanism-aware discovery tools. A company spokesperson stated, "Protein interactions shape nearly every biological process. Our goal is to give researchers technologies that not only generate data but help them understand the story behind that data." More information about Creative Biolabs' technology platforms and yeast two-hybrid services is available at https://www.creative-biolabs.com/.
