Lionheart Health, Inc. has announced that enrollment is opening for its Lionheart Klotho-Up™ Study, a longitudinal program designed to assess whether a structured wellness and bioelectric intervention program may help support key markers of healthy aging. The study focuses on the protein Klotho, which is widely recognized as an important longevity-associated protein linked to multiple aspects of healthy aging, including muscle function, brain health, vascular health, and inflammation balance.
The study is built around two core required elements: daily Klotho-favoring meals, supplements, and beverages, and BodStim™ Klotho-enhancing exercise performed two or three times per week. Participants may also choose from optional supportive therapies, which could include hyperbaric oxygen therapy, red light therapy, cold therapy, pulsed electromagnetic field (PEMF) therapy, and organ-targeted bioelectric stimulation, depending on availability and site offerings. Howard Leonhardt, Executive Chairman and co-CEO of Lionheart Health, stated the company's goal is to make a Klotho-supportive lifestyle more structured, measurable, and accessible, moving beyond vague longevity advice to a guided program with objective testing.
All participants must complete a formal informed patient consent process and agree to required assessments at baseline and one year. These core assessments measure muscle health (via grip strength, gait speed, a 6-minute walk test, and muscle mass), brain health (via standardized cognitive testing, memory testing, and mood assessment), and immune health (via gut intelligence testing and various biomarkers). Additionally, all participants must complete a 461 blood biomarker panel at baseline and one year, with optional testing at 3 and 6 months. An AI-enhanced MRI through CoreViva will be available optionally for deeper body composition insights. For selected candidates at certain international affiliated sites, biologic therapies may also be available under separate, higher-risk consent.
Enrollment is opening on a limited basis for qualified participants at licensed clinic locations as a subsidized paid registry study. Participants will pay $12.99 per day for Klotho-favoring meals delivered to their home or can choose to shop themselves following provided recipes to reduce costs to approximately $5 to $7 per meal. The BodStim™ EMS suit can be leased for one year with an $890 down payment and monthly payments of $188. The 461 biomarker test costs $800 each for non-members and $463 for members. Lionheart Health will cover all required muscle, brain, and immunity health test assessments at baseline and one year, while participants cover the cost of any voluntary additional tests and optional AI-enhanced MRI scans.
This study supports Lionheart Health's participation in XPRIZE Healthspan, where the company was named a Top 40 Milestone 1 awardee semi-finalist from more than 600 registered teams worldwide. The announcement clarifies that the study is intended for research, wellness, and health optimization purposes, requires informed consent, and is not medical advice or a claim of disease treatment. Individual results may vary, and optional therapies are subject to eligibility criteria and regulatory limitations. For more information about the study, eligibility, and participating sites, visit Lionheart Longevity.
