MyBioSource has expanded its research reagent catalog with the addition of a validated sheep anti-rat calretinin (CALB2) polyclonal antibody, designated MBS502148. This antibody specifically targets the 29kDa calretinin protein, a crucial calcium-binding protein predominantly expressed in neurons throughout the central nervous system, retina, and other tissues.
The antibody's development addresses the growing need for reliable research tools in neurobiology and cellular calcium signaling studies. Calretinin plays essential roles in buffering intracellular calcium, maintaining cellular homeostasis, and providing neuroprotection, making it a critical protein for researchers investigating neurological function and dysfunction.
Key technical specifications include the antibody's confirmation through Western blot analysis of rat brain lysate, with purification via Protein A to ensure high specificity and minimal background noise. Researchers can utilize this reagent in multiple validated techniques including Western Blot, Immunohistochemistry on formalin or paraformaldehyde perfused rat brain tissues, and Immunofluorescence applications.
The antibody demonstrates significant cross-species reactivity potential due to 100% sequence homology, making it suitable for research involving mouse, human, and non-human primate samples. This broad applicability enhances its value for comparative studies across different experimental models.
Storage requirements specify maintenance at -20°C with precautions against repeated freeze-thaw cycles to preserve antibody integrity and performance. The product is specifically designed for neuroscience research applications including neurodegeneration studies, calcium signaling mechanisms, cellular calcium buffering research, and auditory neuron investigations.
Calretinin's importance extends beyond basic research as it serves as a valuable marker in neurological studies, particularly in analyzing calcium dynamics and neuronal resistance to excitotoxicity. The protein's neuroprotective roles make this antibody particularly relevant for researchers studying neurological disorders and cellular protection mechanisms.
This addition to MyBioSource's catalog supports academic and research institutions focused on elucidating calcium regulation mechanisms, neuronal function pathways, and related biological processes. The antibody contributes to ongoing research in neurodegeneration, auditory neuroscience, and developmental biology while supporting literature review and experimental validation in these fields.
The anti-CALB2 antibody is intended strictly for research purposes and is not suitable for diagnostic, therapeutic, or clinical applications. Researchers must follow appropriate laboratory safety guidelines and validate antibody performance under their specific experimental conditions to ensure reliable results.
