GeoVax's CM04S1 COVID-19 Vaccine Shows Promise for Immunocompromised Patients in Clinical Trials
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GeoVax Labs, Inc. will present clinical progress for its CM04S1 COVID-19 vaccine candidate at the Emerging Growth Conference on September 25, 2025. The company's interim results from two major international scientific meetings show promising outcomes for immunocompromised patient populations who have not responded adequately to current authorized vaccines.
Phase 2 data presented at the International Workshop on Chronic Lymphocytic Leukemia demonstrated that CM04S1 achieved the study's immune response primary endpoint in chronic lymphocytic leukemia patients, while the comparator mRNA vaccine did not. Based on the Data Safety Monitoring Board recommendation, further enrollment is proceeding exclusively in the CM04S1 arm, indicating strong confidence in the vaccine's performance.
Additional interim results presented at the European Society of Clinical Microbiology and Infectious Disease meeting showed robust, durable T-cell and cross-variant antibody responses in immunocompromised blood cancer and post-transplant patients. Notably, no serious adverse events were reported, reinforcing the vaccine's safety profile and differentiation versus standard-of-care vaccines.
David Dodd, Chairman and CEO of GeoVax, stated that these results underscore CM04S1's promise as a multi-antigen solution for patients left behind by first-generation COVID-19 vaccines. The company's MVA platform is demonstrating potential to deliver broad, durable immune protection where it is needed most, particularly for vulnerable populations with compromised immune systems.
The clinical significance of these findings lies in addressing a critical healthcare gap. Immunocompromised individuals, including cancer patients and transplant recipients, have shown reduced responsiveness to existing COVID-19 vaccines, leaving them particularly vulnerable to severe outcomes. CM04S1's multi-antigen approach appears to overcome these limitations, potentially providing better protection against current and emerging variants.
For more information about the company's clinical trials and updates, visit https://www.geovax.com. The Emerging Growth Conference presentation will be available for replay on https://www.EmergingGrowth.com and their YouTube channel following the live event.
